THE BIOLOGY OF NUCLEAR FACTOR KAPPA BETA (NFkB) IN HEALTH AND PATHOLOGY
Keywords:
NFkB, cancer, inflammation, aging, Alzheimer’s diseaseAbstract
This paper reviewed the molecular roles of NFkB in cell survival, disease, and death. By activating FOXO, nuclear transcription factor-2 (Nrf-2), and mitogen-activated protein kinase (MAPK) signaling mechanisms, NFĸB mediates cell survival mechanisms which guarantee cell viability against pathogenic stimuli. On the other hand, NFĸB could also modulate pathogenic signaling pathways leading to cell degeneration, aging, disease and death. This dual role of NFĸB should be considered into development of novel strategies for tumor killing in cancer patients, or for the preservation of brain neurons in Alzheimer’s disease.
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