Formulation and Evaluation of Fast Disintegrating Tablets of Muscles Relaxants Using Different Super Disintergents

Abstract

Tizanidine hydrochloride is a short-acting drug for the management of spasticity. Tizanidine hydrochloride is an agonist of 2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.The aim of the research was to formulate the fast dissolving tablets of Tizanidine hydrochloride, Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing, attempt was been made to prepare fast dissolving tablets of Tizanidine hydrochlorideusing super disintegrants like  sodium starch glycolate and croscarmellose sodium and the prepared granules were subjected   D.C method. The granules thus prepared were evaluated for hardness, friability, weight variation, in vitro disintegration time and in vitro dissolution study. Compatibility of the drug and the excipients were studied by FTIR spectroscopy ,from the results obtained no interaction between the drug and excipients were observed .From this study it was concluded that fast dissolving tablets of Tizanidine hydrochloride prepared from three different super-disintergrants enhanced dissolution will lead to improved bioavailability, improved the effectiveness of Tizanidine hydrochloride.