Formulation and Evaluation of Fast Disintegrating Tablets Contaning Anti Migrain Drug

Abstract

Sumatriptan succinateis used to treat migraines. It helps to relieve headaches, pain and other symptoms of migraines, including sensitivity to light/sound, nausea, and vomiting. Prompt treatment allows to get back to normal routine and may decrease need for other pain medications. Fast dissolving drug delivery systemoffers a solution for those patients having difficulty in swallowing, attempt has been made to prepare fast dissolving tablets of Sumatriptan succinate using super disintegrants like cros povidone, Crosscarmellose sodium and the prepared granules were subjected D.C method. The granules thus prepared were evaluated for hardness, friability, weightvariation, in vitro disintegration time and in vitro dissolution study. The hardness of the tablet was in range 2.5±0.98-2.9±0.98kg/cm2 .The percentage friability of the tablet was less than 1% , drug content uniformity study results showed that uniform dispersion of the drug throughout the formulation were in between 88.78±0.14%-98.83±0.02% .Weight variation test results showed that tablets were deviating from the average weight within the permissible limit of ± 7.5% .Finally in vitro drug release studies were carried out for 60 minutes that tablets prepared with SSG F2 formulation  showed the release 99.98% in 0.1N HCl.