Synthesis, Characterizationand Anti-Bacterial and Anti-Fungal Activity of Thiazolidin – 4 – One Derivatives
Keywords:
Schiff’s bases, Aromatic aldehyde, Anti-bacterial activity, Anti-fungal activity, Thioglycollic acidAbstract
The Titled compounds have been synthesized by using the reaction among benzoyl chloride and anthranilic acid in presence of pyridine to form intermediate benzoxyzene-four-one which turned into similarly treated with hydrazine hydrate followed by means of condensation of the resulting hydrazones at different aldehyde gives the corresponding schiff’s base compounds (5a-e). Reaction of the schiff’s base compounds with thioglycollic acids furnishes the goal thiazolidin-4-one molecules (6a-e). The newly synthesized compounds had been screened for anti-bacterial and anti-fungal interest via disc diffusion method. Ciprofloxacin and ketaconazole had been used as a preferred for anti-bacterial pastime and anti-fungal pastime respectively.
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