Development and Evaluation of GEL Incorporated with Synthesized Silver Nanoparticle from Aquilaria Malaccensis for the Treatment of Acne Vulgaris
Keywords:
Acne vulgaris, Silver nanoparticle, antibacterial studyAbstract
Acne vulgaris is one among the foremost prevalent skin diseases which affect almost 80% of adolescents within the world during their lifetime. Antibiotic resistance will Develop when we take the antibiotic during repeated treatment. Ancient time onwardsplants are utilised as medicine. Treatment of acne has been considered as a serious research area in pharmaceutical and private cosmetic care industries. The aim of this work was to guage the phytochemical composition of Aquilaria malaccensis , green synthesis of silver nanoparticle and to develop herbal topical gel formulation to treat acne. Aquilaria malaccensis is chosen supported its antibacterial activity. Phytochemical analysis revealed phytoconstituents like alkaloids, flavonoids, tannins and saponins are present within the extract. Silver nanoparticle was synthesized using 1 mM aqueous nitrate from the extracts of Aquilaria malaccensis and formation of silver nanoparticle was confirmed by UV spectroscopy and Functional groups are identified by FTIR analysis. Synthesized silver nanoparticles was incorporated into gel base and evaluated for its physical properties like pH, viscosity, spreadability and antibacterial activity against Propionibacterium acne, Staphylococcus aureus and Escherichia coli.The preparedformulation of this study showing no lumps, had uniform color dispersion and were free from any fibre and particle. it found that the formulation is easy to wash, better spreadability, pH was found to be 6.72 and 6.80 almost like pH of the skin. The developed formulation showed good antibacterial activity against Propionibacterium acne, Staphylococcus aureus and Escherichia coli. Synthesized silver nanoparticle of Aquilaria malaccensis showed higher activity than extract. Hence, silver nanoparticle of Aquilaria malaccensis in aqueous gel-base are often used as an appropriate formulation for treatment of acne.
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