Design and Development of Dexlansoprazole Buccal Tablets
Keywords:
Buccal tablets, Dexlansoprazole, HPMC K4M, ChitosanAbstract
In the present study an attempt was made to formulate and evaluate a new Bucco adhesive tablets for buccal drug delivery of Dexlansoprazole in order to overcome bioavailability related problems, to reduce dose dependent side effects and frequency of administration. Different eight formulations of mucoadhesive buccal tablets were prepared by using HPMCK4M, Chitosan as mucoadhesive polymer in a different concentration by direct compression method. The prepared formulations were evaluated for pre compression and post compression parameters which revealed good flow properties of the blend and physical attributes of the prepared tablets were found to be practically within control limits. The swelling index was proportional to polymer content. The surface pH of all tablets was found to be satisfactory i.e. close to neutral pH hence, buccal cavity irritation should not occur with these tablets. Drug release and drug diffusion from the tablets were depended on the concentration and type of the polymer used in the formulation. FTIR studies showed the compatibility of drug with excipient. From the in-vitro drug release study it was found that formulation F5 has good drug release when compared to other formulations. The formulation F5 containing Dexlansoprazole, Chitosan as mucoadhesive polymer is the optimized formulation. The release data was treated with kinetic equation and it followed zero order release. The mechanism of drug release was found to be Fickians diffusion and followed anomalous release.
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