In-Vitro Dissolution Enhancement of Indomethacin by Liquisolid Technique
Abstract
The present research work involves the development of the liquisolid tablets containing Indomethacinas model drug using liquisolid technique. Initally, liquisolid compacts containing Indomethacin LSCB1 and LSCB2 were prepared using two concentrations 1:1 and 1:05 ratio of non-volatile liquid (Polyethyleneglycol-800) respectively and also carrier material (microcrystalline cellulose) and coating material (aerosil100) were added. Later, Indomethacin liquisolid tablet formulations IMF1, IMF3, IMF5 and formulations IMF2, IMF4, IMF6 are prepared using LSCB1 and LSCB2 liquisolid compacts and different concentration of super-disintegrant (crospovidone) are added for the tablet formulations IMF1-IMF2, IMF3-IMF4 and IMF5-IMF6 was 2%, 4% and 6% respectively. Finally, the liquisolid tablet of Indomethacin was formulated and successfully achieved the enhancement of dissolution rate of Indomethacin using liquisolid technique.
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