Development and in Vitro Evaluation of Edotolac Matrix Tablets
Keywords:
Matrix tablets, Etodolac, Eudragit S 100, HPMCAbstract
The aim of the study was to develop matrix tablets of Etodolac using Eudragit S 100 and HPMC for the treatment of Osteoarthritis. All the formulations (F1 to F5) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Etodolac released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F3 released 95.24% of Etodolac. The results of the study showed that formulation F3 is most likely to provide targeting of Etodolac for local action in the colon owing to its minimal release of the drug in the first 5h. The most satisfactory formulation was stable during stability studies conducted for 60 days as per ICH guidelines. Stability studies showed no significant changes in the physicochemical parameters, in vitro drug release. The studies confirmed that, the designed formulation could be used potentially for controlling the drug release.
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